Engineering PbS/CdS quantum dots for NIR-II multiplexed imaging

Xingjian Zhong; Alexander M. Saeboe; Umar Iqbal; Dongling Zhang; Maria J. Moreno; Allison M. Dennis

doi:10.1117/12.2607967

3 March 2022 Engineering PbS/CdS quantum dots for NIR-II multiplexed imaging

Xingjian Zhong, Alexander M. Saeboe, Umar Iqbal, Dongling Zhang, Maria J. Moreno, Allison M. Dennis

Author Affiliations +

Proceedings Volume PC11977, Colloidal Nanoparticles for Biomedical Applications XVII; PC1197702 (2022) https://doi.org/10.1117/12.2607967
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Fluorescence bioimaging utilizing the near infrared-II (NIR-II; 1000 – 1700 nm) window, also named shortwave infrared (SWIR) imaging, exhibits superior penetration depth and signal-to-noise ratio compared to NIR-I imaging. We synthesized and characterized multiple lead sulfide/cadmium sulfide (PbS/CdS) core/shell quantum dots (QDs) with distinct, monodisperse size distributions, narrow emission, high quantum yield, and photostability for use in multiplexed NIR-II imaging. Following micelle encapsulation, the QDs are water-soluble, stably dispersed, and functionalized for easy click chemistry conjugation with targeting moieties. In vivo mice imaging with IV injected QDs showed very strong and distinctive signals for multiplexed imaging.

Conference Presentation

Citation Download Citation

Xingjian Zhong, Alexander M. Saeboe, Umar Iqbal, Dongling Zhang, Maria J. Moreno, and Allison M. Dennis "Engineering PbS/CdS quantum dots for NIR-II multiplexed imaging", Proc. SPIE PC11977, Colloidal Nanoparticles for Biomedical Applications XVII, PC1197702 (3 March 2022); https://doi.org/10.1117/12.2607967

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KEYWORDS

Multiplexing

Quantum dots

Atmospheric particles

In vivo imaging

Infrared imaging

Infrared radiation

Quantum efficiency

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