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17 March 2023 Photothermal therapy of bacterial infections using phage-nanoparticle conjugates
Irene Chen
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Proceedings Volume PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023; PC1235806 (2023) https://doi.org/10.1117/12.2655641
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Increasing antimicrobial resistance in bacterial pathogens has prompted a renewed interest in alternative approaches, such as bacteriophages (viruses that infect bacteria). However, phage therapy, as traditionally envisioned, suffers from several technical as well as safety challenges. We are developing a platform for controlled phage therapy using engineered filamentous phages coupled with plasmonic nanorods. Studies in our group have validated the safety and efficacy of this approach in vitro and in vivo.
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Irene Chen "Photothermal therapy of bacterial infections using phage-nanoparticle conjugates", Proc. SPIE PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023, PC1235806 (17 March 2023); https://doi.org/10.1117/12.2655641
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KEYWORDS
Nanorods
Safety
Bacteria
Gold
In vitro testing
Mouse models
Pathogens
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