Bioluminescence tomography-guided system for pre-clinical radiation therapy research and quantitative imaging

Zhishen Tong; Xiangkun Xu; Zijian Deng; Ken Kang-Hsin Wang

doi:10.1117/12.2650202

7 March 2023 Bioluminescence tomography-guided system for pre-clinical radiation therapy research and quantitative imaging

Zhishen Tong, Xiangkun Xu, Zijian Deng, Ken Kang-Hsin Wang

Author Affiliations +

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760R (2023) https://doi.org/10.1117/12.2650202
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Bioluminescence tomography (BLT), as an available image-guided system for pre-clinical radiotherapy research, can localize in vivo tumors within high localization accuracy but it is still challenging to recover accurate structure information due to optical diffusion and ill-posed inverse problem. Recognition of this challenge led us develop novel reconstruction method, optimized spectral-derivative compressive sensing conjugate gradient algorithm. We will perform simulation and in vivo experiments to test BLT’s performance in reconstructing the target location and shape both in primary tumor or metastatic setting. We expect that our BLT-guided system will provide investigators quantitative tumor imaging to perform high precision radiation research.

Conference Presentation

Citation Download Citation

Zhishen Tong, Xiangkun Xu, Zijian Deng, and Ken Kang-Hsin Wang "Bioluminescence tomography-guided system for pre-clinical radiation therapy research and quantitative imaging", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760R (7 March 2023); https://doi.org/10.1117/12.2650202

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