Whole slide stimulated Raman imaging device for histology of fresh tissue samples

Maximilian Brinkmann; Maryam Rezaei; Felix Neumann; Ramon Droop; Christoph Engwer; Niklas Lüpken; Sven Dobner; Tim Hellwig

doi:10.1117/12.3001371

13 March 2024 Whole slide stimulated Raman imaging device for histology of fresh tissue samples

Maximilian Brinkmann, Maryam Rezaei, Felix Neumann, Ramon Droop, Christoph Engwer, Niklas Lüpken, Sven Dobner, Tim Hellwig

Author Affiliations +

Proceedings Volume PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; PC128310K (2024) https://doi.org/10.1117/12.3001371
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present a fully integrated, clinical-compatible SRS imaging device giving access to the complete Raman spectrum during tumor surgeries. For detailed examination of larger tissue samples, we have designed a high-speed, low-resolution imaging mode to quickly identify cancerous hot-spots, followed by a high-resolution imaging mode. Leveraging the advantages of a compact and robust fiber laser, we have integrated the entire microscopy system into a clinical cart, facilitating deployment in diverse clinical environments. The laser provides rapid tunability within milliseconds across a broad spectral range of 700 to 3300 1/cm, covering biomedically relevant resonances in the fingerprint region.

Conference Presentation

Citation Download Citation

Maximilian Brinkmann, Maryam Rezaei, Felix Neumann, Ramon Droop, Christoph Engwer, Niklas Lüpken, Sven Dobner, and Tim Hellwig "Whole slide stimulated Raman imaging device for histology of fresh tissue samples", Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC128310K (13 March 2024); https://doi.org/10.1117/12.3001371

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