Endobronchial multipath contrast imaging of vascular networks and lung cancer

Adrian Tanskanen; Jeanie Malone; Eric Brace; Renelle S. Myers; Tawimas S. Shaipanich; Stephen S. Lam; Calum S. MacAulay; Pierre S. Lane

doi:10.1117/12.3003313

13 March 2024 Endobronchial multipath contrast imaging of vascular networks and lung cancer

Adrian Tanskanen, Jeanie Malone, Eric Brace, Renelle S. Myers, Tawimas S. Shaipanich, Stephen S. Lam, Calum S. MacAulay, Pierre S. Lane

Author Affiliations +

Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC1283406 (2024) https://doi.org/10.1117/12.3003313
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We have previously demonstrated multimodal optical coherence tomography and autofluorescence imaging (OCT-AFI) in the distal airways of the lung. To combine the two modalities into a single-fiber endoscope, we use double-clad fibers, which causes additional blurred OCT images from the fibers' higher-order modes. Recently, we established multipath contrast imaging (MCI) which leverages these higher-order images to elucidate angular backscattering of tissue. MCI can be generated retroactively; we seek to re-evaluate images from our in vivo OCT-AFI lung cancer study. Early MCI results demonstrate high contrast in healthy tissue compared to blood, and for a histologically confirmed adenocarcinoma.

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Adrian Tanskanen, Jeanie Malone, Eric Brace, Renelle S. Myers, Tawimas S. Shaipanich, Stephen S. Lam, Calum S. MacAulay, and Pierre S. Lane "Endobronchial multipath contrast imaging of vascular networks and lung cancer", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC1283406 (13 March 2024); https://doi.org/10.1117/12.3003313

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