Translational optical coherence elastography for assessment of systemic sclerosis

Kirill V. Larin; Shervin Assassi

doi:10.1117/12.3005448

13 March 2024 Translational optical coherence elastography for assessment of systemic sclerosis

Kirill V. Larin, Shervin Assassi

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440T (2024) https://doi.org/10.1117/12.3005448
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Systemic sclerosis (SSc-scleroderma) is an autoimmune disorder resulting in excessive collagen accumulation in the skin and internal organs. Currently, the modified Rodnan Skin Score (mRSS) is the gold standard for evaluating dermal thickening due to SSc. However, mRSS has noticeable inter- and intra-observer variabilities as quantified by the interclass correlation coefficient ICC: 0.6-0.75. In this work, optical coherence elastography (OCE) combined with structural and functional optical coherence tomography (OCT) image analysis was used to assess skin thickness in 57 SSc patients and 19 healthy volunteers. The data also demonstrate that OCT/OCE could outperform semi-quantitative clinical assessments such as mRSS. Overall, these results demonstrate that OCT/OCE could be useful for rapid, noninvasive, and objective assessments of SSc onset and monitoring skin disease progression and treatment response.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Kirill V. Larin and Shervin Assassi "Translational optical coherence elastography for assessment of systemic sclerosis", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440T (13 March 2024); https://doi.org/10.1117/12.3005448

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