A Preliminary Study For An Empirical Approach To An Optical Transform Method For Differentiation Of Pathologies Found In Human Blood Cell Smears

James H. K. Yoo

doi:10.1117/12.955937

27 December 1977 A Preliminary Study For An Empirical Approach To An Optical Transform Method For Differentiation Of Pathologies Found In Human Blood Cell Smears

James H. K. Yoo

Author Affiliations +

Proceedings Volume 0127, Application of Optical Instrumentation in Medicine VI; (1977) https://doi.org/10.1117/12.955937
Event: Application of Optical Instrumentation in Medicine VI, 1977, Boston, United States

Abstract

A pilot study for potential applicability of a coherent optical. Fourier transform technique to differentiate between healthy and pathological human blood cell smears has been conducted. Types of abnormalities tested include acute myelogenous leukemia, sickle-cell anemia, target-cell anemia, acute lymphatic leukemia, infectious mononucleosis,and eosincphila. Although limited numbers of slides and restricted types of abnormalities were examined, normality and various abnormalities are distinctly identifiable through coherent optical transform analysis. The morphological and constitutional variations have been qualitatively examined as the sources of both the observed deviations in the characteristic transform patterns and the photographic or densitometric profiles. Limitations in the presently employed optical Fourier transform method and the prerequisite conditions for standardized sample preparation are briefly discussed.

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James H. K. Yoo "A Preliminary Study For An Empirical Approach To An Optical Transform Method For Differentiation Of Pathologies Found In Human Blood Cell Smears", Proc. SPIE 0127, Application of Optical Instrumentation in Medicine VI, (27 December 1977); https://doi.org/10.1117/12.955937

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