Both nuclear and computerized cardiovascular imaging are being evaluated for use in assessing myocardial integrity. The general approach used in assessing myocardial integrity by positron emission tomography consists of the administration of a radiopharmaceutical label with a positron-emitting radionuclide followed by the imaging of the distribution of the label within the myocardium as a func-tion of time. Spatial resolution is currently limited to approximately 1 cm and the measurements currently require several minutes. Although technological advances in transmission computed tomography have been dramatic, its myocardial applications are currently limited by inadequate temporal resolution and difficul-ties in timing the scan exposure to coincide with maximum contrast enhancement. Dynamic scanning (multiple scans in rapid succession), gated, and rapid scans (less than 500 milliseconds) are currently being developed. Modest improvements can be expected with existing technology and optimization of reconstruction algorithms.