The Measurement Of Retinal Blood Velocity With Laser Doppler Anemometry

V. Highman; Y. Levy; N. S. Vlachos; J. H. Whitelaw

doi:10.1117/12.958360

29 May 1980 The Measurement Of Retinal Blood Velocity With Laser Doppler Anemometry

V. Highman, Y. Levy, N. S. Vlachos, J. H. Whitelaw

Proceedings Volume 0211, Optics and Photonics Applied to Medicine; (1980) https://doi.org/10.1117/12.958360
Event: Optics, Photonics, and Iconics Engineering Meeting, 1979, Strasbourg, France

Abstract

Clinical evidence suggests that blood flow in the retinal vessels varies in progressing diabetic retinopathy with a significant increase in the advanced stages. The changes of the flow in the blood vessels may serve as a monitor of the disease. Despite their importance direct blood flow velocity measurements are not easily obtainable. The paper communicates recent advances in the development of a laser Doppler anemometer for the determination of in-vivo retinal blood velocity and provides information relevant to the flow of blood in the human retina. The anemometer is integrated, self-aligning and operates with backscattered light. The influence of the important design parameters is qualified. Problems of light absorption and diffusion by blood corpuscles pertinent to laser Doppler anemometry as well as focussing of the control volume on the retinal arteries are discussed as is the influence of wall scattering on the signal-to-noise ratio. The optical arrangement used for this purpose can, with small modification, be fitted to a slit lamp for simultaneous clinical observations and measurements in the human retina. For the present measurements, it was used to obtain measurement with blood flowing in glass tubes of inside diameter 75 and 100μm. Based on experience with two methods of processing the Doppler signals, an alternative approach is proposed.

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V. Highman, Y. Levy, N. S. Vlachos, and J. H. Whitelaw "The Measurement Of Retinal Blood Velocity With Laser Doppler Anemometry", Proc. SPIE 0211, Optics and Photonics Applied to Medicine, (29 May 1980); https://doi.org/10.1117/12.958360

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KEYWORDS

Blood

Velocity measurements

Doppler effect

Retina

Signal processing

Blood circulation

Laser Doppler velocimetry

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