An important parameter in an image intensifier-based imaging system is the contrast of the image intensifier tube itself. This paper presents a photographic method for the measurement of the large-scale contrast of an image intensifier tube at the system level which can be performed in the clinical setting with equipment normally found in a modern Radiology Department. A strip of Lead is positioned on-center at the bottom of the grid so that a line image of 100% contrast will be presented to the input phosphor of the image intensifier when the x-ray tube is energized at low kilovoltage. The output phosphor is photographed either with an existing fluorographic camera (photospot or cine) on the imaging tower, or with a 35-mm SLR camera loaded with orthochromatic cine film through the collimating lens of the system from the position normally occupied by the television camera, during fluoroscopy, if no other camera is present on the imaging tower. The resultant on-frame optical density is measured with a densitometer in the central part of the developed frame adjacent to and behind the image of the Lead strip. These optical density readings are converted into a ratio of light intensities from the corresponding regions on the output phosphor using the characteristic curve for the type of film employed, which is obtained by means of light sensitometry. The percent contrast is then calculated from (ratio of intensities - 1)/(ratio of intensities + 1)) X 100. Using data for a variety of CsI image intensifiers used for both gastrointestinal and vascular studies, the method is shown to give measured percent contrasts with a reproducibility of no worse than-2%, independent of type of camera used or type of sensitometer used. Standards of acceptable performance based on the author's experience with this technique over the past five years are presented for systems designed for Barium studies and for systems designed for Iodine studies. The relationship between the percent contrast as defined here, the veiling glare as defined by Siedband, and the contrast ratio as normally defined is discussed, as well as the relevance of large-scale contrast of an image intensifier tube.