With inception of the Space Shuttle Program and the evolution of payload systems and instruments to ultrasensitive levels, the vulnerability of payload systems and instruments to the induced contamination environment has become a prime consideration in mission operations and hardware design. This paper presents the current management philosophies and the systems level approach being applied to payload integration to address the discipline of contamination and insure its control. Applicable documentation and the status of the current contamination data base are discussed. Existing analytical tools and their applicability to integration analysis are presented, and typical analysis results are provided. All program phases from initial concept design through ground operations and on-orbit activities are addressed as related to state-of-the-art technology and management philosophy. The status of this approach as applied to current Shuttle integration activities with NASA, DOD, and spacecraft contractors is presented to reveal basic problems which exist in such areas as spacecraft contamination requirements, KSC ground facility cleanliness control and weaknesses in analytical tools and related data bases. Ultimately, recommendations are provided for improvements deemed necessary to refine the technology of payload contamination integration.