The principal advantages of the high voltage electron microscope, higher resolution, penetrating power, decreased radiation damage and the special effects of critical voltage and displacement damage are outlined. Some application of increased penetration and radiation damage to studies in materials science are then discussed in more detail.
M. J. Goringe, M. J. Goringe,
"Applications Of High Voltage Electron Microscopy In Materials Science", Proc. SPIE 0368, Microscopy: Techniques and Capabilities, (29 March 1983); doi: 10.1117/12.934323; https://doi.org/10.1117/12.934323