The Hubble Space Telescope (herein identified as the Space Telescope) is the largest and most powerful optical and ultraviolet astronomical observatory to be operated in space. From its nominal 550-600 kilometer low Earth orbit, the Space Telescope will produce data including imagery of unequaled quality of galaxies, star systems, quasars and other objects of scientific interest. Responding to a set of demanding scientific requirements, the optical, attitude control, stabilization and other equally vital subsystems of the Space Telescope are sophisticated and represent a high level of design quality. This paper describes the systems engineering program established for the Space Telescope, a project managed by the Marshall Space Flight Center (MSFC) of the National Aeronautics and Space Administration (NASA). The planning and operational methods implemented by the systems engineering organization to ensure that the scientific requirements are satisfied, that the verification process is acceptable, and that the configuration is controlled are described.