The First Spacelab Mission began in the mid seventies as a joint NASA/ESA multidisciplinary scientific mission with the prime objective of verifying the Spacelab Design and performance and to demonstrate the Spacelab ability as a scientific laboratory. The planning for the mission established many new concepts for management and space experimentation and dealt with a whole era in space transportation. In reviewing the first mission, the management and technical approach for the overall mission design will be examined against the original concept. The highlights and accomplishments of the mission will be presented. The lessons learned and how they may be applicable to future Spacelab Missions will be discussed.