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24 October 1984 Effects Of Continuous Argon Laser Irradiation On Canine And Autopsied Human Cardiac Tissue
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Abstract
In eight human formalin preserved cardiac specimens, various cardiac and vascular obstructions were relieved by argon laser irradiation. Interatrial communication was also produced by a transar'rial approach in a live dog. In-vivo fresh canine cardiac tissues required power density of at feast 80, 90, and 110 watts/cm2 for vaporization of myocardial, vascular and valvular tissues respectively. The fiber tip to tissue distance (effective irradiation distance) for effective vaporization was less than I mm for vascular and valvular tissues and less than 4 mm for myocardium. Light microscopy showed four zones of histological damage common to all tissues - central crater surrounded by layers of charring, vacuolization and coagulation necorsis. Myocardium showed additionally a layer of normal appearing muscle cells (skip area) surrounded by a peripheral coagulation halo. Laser irradiation effects on valvular tissue showed the most lateral extension of coagulation necrosis. It is concluded that palliation and treatment of certain congenital heart defects by laser irradiation is anatomi-cally feasible and may be safe for in vivo application when low power output and short exposure time are used from a very short irradiation distance.
© (1984) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Giora Ben-Shachar, Mark Sivakoff, Steven L. Bernard, Beverly B. Dahms, and Thomas A. Riemenschneider "Effects Of Continuous Argon Laser Irradiation On Canine And Autopsied Human Cardiac Tissue", Proc. SPIE 0494, Novel Optical Fiber Techniques for Medical Applications, (24 October 1984); https://doi.org/10.1117/12.943911
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