Glaucoma is a disease characterized by increased ocular pressure with optic nerve atrophy and loss of visual field, or side vision, which eventually leads to blindness. The optic disc becomes more cupped with increasing progress of the disease. We have devised a system for the use of the Donaldson simultaneous stereophotographic fundus camera to obtain optimal reproducibility and sensitivity of measurements from optic disc stereophotographs. Stereomodel deformations caused by eye-to-camera optical variables (photographic magnification, working distance, relative orientation between the camera optical axis and the optic disc, and position of the optic disc image in the film frame) were evaluated. We developed an analytical correction method for stereomodel deformations and evaluated the impact on measurement of optic disc cupping. We have evaluated the reproducibility of new techniques for measurement of cup parameters such as volume, depth, and area of the cup relative to the disc area; slope of the cup floor, wall, and rim; and cup shape using volume profiles in which contour areas were plotted of the cup depth from the top to the bottom.