This report describes instrumentation used to non-invasively quantitate lens changes and to moniter the development of cataract formation. Quasi-elastic light scattering spectroscopy is used to investigate quarternary lens protein structural changes and lens autofluorescence measurements are used to moniter changes in lens fluorophore concentration. These measurements can be used to investigate the mechanisms of cataract development and to identify those patients showing an accelerated progression in cataracto-genesis.
S E. Bursell,
M. S. Craig,
D. P. Karalekas,
"Diagnostic Evaluation of Human Lenses", Proc. SPIE 0605, Optical and Laser Technology in Medicine, (5 August 1986); doi: 10.1117/12.956355; https://doi.org/10.1117/12.956355