Photosensitization Of Model Membranes By HPD: Implications For Photodynamic Therapy

Leonard I. Grossweiner

doi:10.1117/12.937332

10 March 1987 Photosensitization Of Model Membranes By HPD: Implications For Photodynamic Therapy

Leonard I. Grossweiner

Proceedings Volume 0712, Lasers in Medicine; (1987) https://doi.org/10.1117/12.937332
Event: Cambridge Symposium-Fiber/LASE '86, 1986, Cambridge, MA, United States

Abstract

The photosensitizing properties of hematoporphyrin derivative (HPD) have been investigated using egg phosphatidylcholine liposomes and resealed bovine erythrocyte membranes (ghosts) as model membranes. The results demonstrate that incorporated HPD photosensitizes lipid peroxidation in liposome and ghost membranes and protein cross-linking in ghosts via the Type 2, singlet oxygen mechanism.

Citation Download Citation

Leonard I. Grossweiner "Photosensitization Of Model Membranes By HPD: Implications For Photodynamic Therapy", Proc. SPIE 0712, Lasers in Medicine, (10 March 1987); https://doi.org/10.1117/12.937332

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