The Space Station will be a very complex, closed system. A relatively small crew will be required to manage the day-to-day activities of the Station and to tend the experimental and commercial payloads. Decisions will be required concerning the operation and maintenance of all the elements of the Station. The emerging technology of artificial intelligence is being utilized to build expert system software which will provide the routine reasoning and problem-solving capabilities required to off-load the crew for more productive tasks. The complex problem of building these expert systems and the man-machine interfaces which make them effective are the subjects of this paper.