Biomedical specimens can be considered as the most difficult type of samples for scanning acoustic microscopy, since modulation by structural properties is low, the coupling medium often cannot be heated up to improve its transmission properties, and small structural details call for high frequencies where the signal-to-noise ratio is low. A microscope developed at Ernst Leitz Wetzlar GmbH using state of the art technology to reduce these problems is described. Applicational examples are given proving both high resolution performance and high signal-to-noise ratio under critical conditions.
Martin Hoppe, Martin Hoppe,
"Technical Aspects Of High Resolution Scanning Acoustic Microscopy Of Biomedical Samples", Proc. SPIE 0809, Scanning Imaging Technology, (3 August 1987); doi: 10.1117/12.941513; https://doi.org/10.1117/12.941513