Hydrophobic Versus Hydrophilic Drugs For PDT

Alan R. Morgan; Greta M. Garbo; Rick W. Keck; Steven H. Selman

doi:10.1117/12.942709

19 February 1988 Hydrophobic Versus Hydrophilic Drugs For PDT

Alan R. Morgan, Greta M. Garbo, Rick W. Keck, Steven H. Selman

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942709
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

In recent years, a number of new photosensitizers have been developed for the photo-dynamic treatment of cancer. These new drugs include tetrasulfonated phthalocyanines, tetra(hydroxypheny1) porphyrins, chlorins and purpurins which are water soluble, and phthalocyanines, chlorins, purpurins and verdins which are water insoluble. In vivo or in vitro data are available to assess the relative photodynamic efficiency of either hydrophobic or hydrophilic sensitizers. Hydrophobic drugs require a more complex delivery system in order to overcome their water insolubility. In this paper, we report the suitability of both oil-based emulsions and unilamellar liposomes for in vivo delivery of three different photosensitizers (a purpurin, a verdin and a chlorin).

Citation Download Citation

Alan R. Morgan, Greta M. Garbo, Rick W. Keck, and Steven H. Selman "Hydrophobic Versus Hydrophilic Drugs For PDT", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942709

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