Liposomes As Carriers Of Hydrophobic Photosensitizers In Vivo: Increased Selectivity Of Tumor Targeting

Fernanda Ricchelli; Roberta Biolo; Elena Reddi; Giuseppe Tognon; Giulio Jori

doi:10.1117/12.942696

19 February 1988 Liposomes As Carriers Of Hydrophobic Photosensitizers In Vivo: Increased Selectivity Of Tumor Targeting

Fernanda Ricchelli, Roberta Biolo, Elena Reddi, Giuseppe Tognon, Giulio Jori

Author Affiliations +

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942696
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Unilamellar liposomes of dipalmitoyl-phosphatidylcholine (DPPC) incorporate a variety of hydrophobic photosensitizers (e.g. hematoporphyrin dimethylester, unsubstituted phthalo-cyanines, porphycene) into the phospholipid bilayer. The physico-chemical properties of the liposome-bound photosensitizers in the ground and electronically excited states can be characterized by steady-state and time-resolved fluorescence spectroscopy. The liposome-drug system is stable under physiological conditions and, once injected into tumor-bearing animals, selectively delivers the photosensitizer to serum lipoproteins. As a consequence, the tumor uptake of the drug via receptor-mediated endocytosis of low-density lipoproteins (LDL) is favoured. This leads to a larger ratio between the photosensitizer concentration in the tumor and adjacent normal tissues, hence to an increased efficacy of the photodynamic therapy (PDT).

Citation Download Citation

Fernanda Ricchelli, Roberta Biolo, Elena Reddi, Giuseppe Tognon, and Giulio Jori "Liposomes As Carriers Of Hydrophobic Photosensitizers In Vivo: Increased Selectivity Of Tumor Targeting", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942696

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available