A series of structurally related modified porphyrins have been synthesized. Each compound was tested for in vivo cytotoxicity against the FANFT-induced rat bladder tumor (designated AY-27). An attempt was then made to correlate the amount of tumor necrosis shown on examination of histologic sections of treated tumors, both four and twenty four hours after phototherapy, with the structure of each photosensitizer.
Alan R. Morgan,
"New Dyes For Photodynamic Therapy", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942707; https://doi.org/10.1117/12.942707