Predicting In Vivo Phototoxicity In The Lens Using In Vitro And Photophysical Studies

Joan E. Roberts; James Dillon

doi:10.1117/12.942701

19 February 1988 Predicting In Vivo Phototoxicity In The Lens Using In Vitro And Photophysical Studies

Joan E. Roberts, James Dillon

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942701
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Photodynamic Therapy is an effective treatment of malignant tumors. However the Rophyrin dyes Erggently used are associated with phototoxic effects in the skin and the eye Numerous new dyes are being developed which will hopefully combine effectiveness in treating tumors with fewer phototoxic side effects. We report here a method to assess the relative phototxicity of porphyrins in lenticular tissues that involves both in vitro, photophysical and in vivo studies. This methodology can be used to screen for potential phototoxic side effects of new photosensitizing drugs as they are being developed and to develop means by which that damage may be prevented.

Citation Download Citation

Joan E. Roberts and James Dillon "Predicting In Vivo Phototoxicity In The Lens Using In Vitro And Photophysical Studies", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942701

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