As the title of this paper suggests, it is about CD-ROM technology and the structuring of massive databases. Even more, it is about the impact CD-ROM has had on the publication of massive amounts of information, and the unique qualities of the medium that allows for the most sophisticated computer retrieval techniques that have ever been used. I am not drawing on experience as a pedant in the educational field, but rather as a software and database designer who has worked with CD-ROM since its inception. I will be giving examples from my company's current applications, as well as discussing some of the challenges that face information publishers in the future. In particular I have a belief about what the most valuable outlet can be created using CD-ROM will be: The CD-ROM is particularly suited for the mass delivery of information systems and databases that either require or utilize a large amount of computational preprocessing to allow a real-time or interactive response to be achieved. Until the advent of CD-ROM technology this level of sophistication in publication was virtually impossible. I will further explain this later in this paper. First, I will discuss the salient features of CD-ROM that make it unique in the world of data storage for electronic publishing.