21 June 1988 Intravascular Fiberoptic Detection Of D2O Concentration In Blood.
Author Affiliations +
Proceedings Volume 0906, Optical Fibers in Medicine III; (1988) https://doi.org/10.1117/12.945273
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States
The recent development of low-loss infrared zirconium fluoride fibers allows remote sensing of infrared signals. In this paper a detection device for the intravascular measurement of substances absorbing in the infrared wave length range is described. The applicability of the technique is demonstrated by the measurement of small concentrations of heavy water (D20) in blood. The method is based on the well-known fact that D20 strongly absorbes radiation in the 4 μm range while H2O and blood are comparably well transmitted at that wave length. A catheter was designed that can be inserted in arterial blood vessels. The catheter tip is constructed such that the radiation is guided by the fiber to a gold reflector. Between the reflector and the fiber, blood is withdrawn through a gap of ca. 0.1 mm. The radiation thus passes the medium twice and is guided back to the same fiber. Concentrations below 1 ml D20/1000 ml blood can be determined accurately and indicator kinetics can be recorded with time constants of the entire system below 0.05 s. The advantages of this technique are the low withdrawal rate and neglectable delay of the recorded indicator kinetics and no need for reinfusion of blood. D20 has been used to determine physiological parameters such as extravascular lung water, cardiac output and total body water. The study demonstrates that such measurements are feasable with the described fiberoptic device and that the fiberoptic approach offers distinct advantages over conventional blood withdrawal methods with external analysis. Injectate volumes as small as 0.05 ml/kg body weight are sufficient to obtain indicator kinetics with acceptable signal to noise ratio. By use of appropriate filters concentrations of other substances and their intravascular kinetics can be measured. According to their physicochemical properties a variety of information on physiological parameters appears to be accessible with this approach.
© (1988) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
J. Bock, J. Bock, E. Gersing, E. Gersing, F. Sundmacher, F. Sundmacher, G. Hellige, G. Hellige, } "Intravascular Fiberoptic Detection Of D2O Concentration In Blood.", Proc. SPIE 0906, Optical Fibers in Medicine III, (21 June 1988); doi: 10.1117/12.945273; https://doi.org/10.1117/12.945273

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