Constrained Tryptophan Has A Monoexponential Decay

Melissa C Sattler; William R Cherry; Mary D Barkley

doi:10.1117/12.945389

24 June 1988 Constrained Tryptophan Has A Monoexponential Decay

Melissa C Sattler, William R Cherry, Mary D Barkley

Proceedings Volume 0909, Time-Resolved Laser Spectroscopy in Biochemistry; (1988) https://doi.org/10.1117/12.945389
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States

Abstract

The fluorescence decay of tryptophan is complex. Various models have been proposed to account for the multiexponential decay, including ground-state rotamers, excited-state proton transfer, and lifetime distributions.^1-4 In order to test the rotamer model, we are studying a series of tryptophan derivatives in which rotation about the Ca-CB and CB-Cy, bonds is constrained. The ground-state conformations are determined by X-ray diffraction, molecular and 1H NMR. Or preliminary results for a tryptophan derivative with the a-amino group incorporated in a six-member ring are described below.

Citation Download Citation

Melissa C Sattler, William R Cherry, and Mary D Barkley "Constrained Tryptophan Has A Monoexponential Decay", Proc. SPIE 0909, Time-Resolved Laser Spectroscopy in Biochemistry, (24 June 1988); https://doi.org/10.1117/12.945389

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