A broad area of applications for processing and analysis of medical images can be found with images that are not computer generated, such as radiographic or cytological images. Success when processing and analysing these images depends very much on the quality of the image acquisition system. An image acquisition system based on a CCD linear image sensor was built for the acquisition of chest radiographs. CCDs provide a wide dynamic range and very high spatial resolution, and are well suited for high quality image acquisition systems. These abilities are however reduced considering the variations between the output characteristics of different sensing elements. The digitizer that was built has specially designed hardware for real-time correction of these variations. The digitizer is based on a microcomputer that manages the overall system operations (e.g., calibration, image acquisition, scanning control, light control, fault detection, etc...) and programs the real-time correction hardware. The combination of the CCD image sensor and the correction hardware proved to be quite powerful and effective, taking into account the measurements that were made. The paper discusses the use of CCD image sensors and their characteristics, and describes in detail the algorithms and hardware that were used. It finally points out prospective applications for these type of digitizers, namely in the digitization of radiographic images in a PACS environment.