27 June 1988 A Microcomputer Based Charge Coupled Device (CCD) Imaging System For Clinical 2D Electrophoretic Gel Analysis
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Abstract
We have developed a prototype microcomputer based gel reader for the digitization and semi-automatic analysis of two dimensional polyacrylamide electrophoretic gels. The system uses a 2D charge coupled device (CCD) detector and operates as a peripheral to an IBM PC XT/AT type host computer. The system incorporates a comprehensive software package which lends itself to highly structured clinical applications as well as a wide range of image processing functions for use in the research laboratory. The system is undergoing further development in order to arrive at a comprehensive, low cost, early disease screening device. Electrophoretic gel samples of protein components obtained from subject patients are digitized and searched for anomalous features. These features are located using a digital reference library of disease related protein features and a probability of detection of the disease related protein is computed. The system then presents the physician with a report advising him of the results of the analysis. We describe the hardware and software system and present results of a sample gel analysis.
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Brian L. Craine, Brian L. Craine, Eric R. Craine, Eric R. Craine, John R. Engel, John R. Engel, Neil T. Wemple, Neil T. Wemple, } "A Microcomputer Based Charge Coupled Device (CCD) Imaging System For Clinical 2D Electrophoretic Gel Analysis", Proc. SPIE 0914, Medical Imaging II, (27 June 1988); doi: 10.1117/12.968676; https://doi.org/10.1117/12.968676
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