17 March 1989 Antineoplastic And Antiviral Properties Of Merocyanine 540
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Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960195
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States
Abstract
Simultaneous exposure to the lipophilic photosensitizer, merocyanine 540, and light in the presence of serum (or certain serum components) and oxygen kills leukemia cells, lymphoma cells, neuroblastoma cells, cell-free enveloped viruses, cell-associated enveloped viruses, and virus-infected cells. The same treatment spares pluripotent hematopoietic stem cells, mature erythrocytes, factor VIII, von Willebrand factor, and probably other blood components. Merocyanine 540-mediated photosensitization is now being evaluated clinically as a means to eliminate residual tumor cells from autologous remission bone marrow grafts and preclinically as a means to inactivate pathogenic viruses in blood products.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Fritz Sieber, Fritz Sieber, } "Antineoplastic And Antiviral Properties Of Merocyanine 540", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960195; https://doi.org/10.1117/12.960195
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