Phototoxicity Of Rhodamine Dyes

Christopher R. Shea; Norah Chen; Tayyaba Hasan

doi:10.1117/12.960184

17 March 1989 Phototoxicity Of Rhodamine Dyes

Christopher R. Shea, Norah Chen, Tayyaba Hasan

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960184
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

Rhodamine-123 (R123) and tetrabromo-R123 (TBR) have been evaluated in vitro as potential photosensitizers. R123 localizes selectively in mitochondria of MGH-V1 bladder carcinoma cells exposed to 10 pM R123 for 30 min, and under these conditions R123 is a weak photosensitizes. Incubation with R123 for longer times enhances its phototoxicity, and is associated with a modification of its intracellular localization. TBR is approximately 100 times more phototoxic than R123, as assessed either by 3H-thymidine uptake or vital staining. Actively proliferating cells are more sensitive to either R123 or TBR phototoxicity than are plateau-phase, confluent cultures.

Citation Download Citation

Christopher R. Shea, Norah Chen, and Tayyaba Hasan "Phototoxicity Of Rhodamine Dyes", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960184

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