Increased selectivity and efficacy in photochemotherapy may be achieved by the use of monoclonal antibodies (Mabs) bound to chromophores. Due to their antigen recognition capabilities, Mabs can potentially deliver higher concentrations of chromophores to target tissue while sparing normal tissue. A brief review of the current status of antibody-mediated selective phototoxicity is presented.
T. Hasan, T. Hasan,
"Selective Phototoxicity Using Monoclonal Antibody-Chromophore Conjugates", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960183; https://doi.org/10.1117/12.960183