The Geostationary Operational Environmental Satellite-R series (GOES-R) will be the next generation of NOAA geostationary environmental satellites. The first satellite in the series is planned for launch in November 2016. The satellite will carry six instruments dedicated to the study of the Earth’s weather, lightning mapping, solar observations, and space weather monitoring. Each of the six instruments require specialized calibration plans to achieve their product quality requirements. In this talk we will describe the overall on-orbit calibration program and data product release schedule of the GOES-R program, as well as an overview of the strategies of the individual instrument science teams. The Advanced Baseline Imager (ABI) is the primary Earth-viewing weather imaging instrument on GOES-R. Compared to the present on-orbit GOES imagers, ABI will provide three times the spectral bands, four times the spatial resolution, and operate five times faster. The increased data demands and product requirements necessitate an aggressive and innovative calibration campaign. The Geostationary Lightning Mapper (GLM) will provide continuous rapid lightning detection information covering the Americas and nearby ocean regions. The frequency of lightning activity points to the intensification of storms and may improve tornado warning lead time. The calibration of GLM will involve intercomparisons with ground-based lightning detectors, an airborne field campaign, and a ground-based laser beacon campaign. GOES-R also carries four instruments dedicated to the study of the space environment. The Solar Ultraviolet Imager (SUVI) and the Extreme Ultraviolet and X-Ray Irradiance Sensors (EXIS) will study solar activity that may affect power grids, communication, and spaceflight. The Space Environment In-Situ Suite (SEISS) and the Magnetometer (MAG) study the in-situ space weather environment. These instruments follow a calibration and validation (cal/val) program that relies on intercomparisons with other space-based sensors and utilize special spacecraft maneuvers. Given the importance of cal/val to the success of GOES-R, the mission is committed to a long-term effort. This commitment enhances our knowledge of the long-term data quality and builds user confidence. The plan is a collaborative effort amongst the National Oceanic and Atmospheric Administration (NOAA), the National Institute of Standards and Technology (NIST), and the National Aeronautics and Space Administration (NASA). It is being developed based on the experience and lessons-learned from the heritage GOES and Polar-orbiting Operational Environmental Satellite (POES) systems, as well as other programs. The methodologies described in the plan encompass both traditional approaches and the current state-of-the-art in cal/val.