The aim of this research work is to understand natural and environmental vulnerability situation and its cause such as intensity, distribution and socio-economic effect in the Indigirka River basin, Eastern Siberia, Russia. This paper identifies, assess and classify natural and environmental vulnerability using landscape pattern from multidisciplinary approach, based on remote sensing and Geographical Information System (GIS) techniques. A model was developed by following thematic layers: land use/cover, vegetation, wetland, geology, geomorphology and soil in ArcGIS 10.2 software. According to numerical results vulnerability classified into five levels: low, sensible, moderate, high and extreme vulnerability by mean of cluster principal. Results are shows that in natural vulnerability maximum area covered by moderate (29.84%) and sensible (38.61%) vulnerability and environmental vulnerability concentrated by moderate (49.30%) vulnerability. So study area has at medial level vulnerability. The results found that the methodology applied was effective enough in the understanding of the current conservation circumstances of the river basin in relation to their environment with the help of remote sensing and GIS. This study is helpful for decision making for eco-environmental recovering and rebuilding as well as predicting the future development.