Modulating molecular transport across peptide-modified nanoporous alumina membranes with light

Tushar Kumeria; Jingxian Yu; Mohammed Alsawat; Mahaveer D. Kurkuri; Abel Santos; Andrew D. Abell; Dusan Losic

doi:10.1117/12.2241495

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9 December 2016 Modulating molecular transport across peptide-modified nanoporous alumina membranes with light

Tushar Kumeria, Jingxian Yu, Mohammed Alsawat, Mahaveer D. Kurkuri, Abel Santos, Andrew D. Abell, Dusan Losic

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Proceedings Volume 10013, SPIE BioPhotonics Australasia; 100131W (2016) https://doi.org/10.1117/12.2241495
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

We designed and fabricated a smart and stimuli responsive membrane to cater on demand molecular transporting applications. A novel photoswitchable peptide (PSP) was synthesized and attached inside nanoporous anodic alumina membranes (NAAMs) pores. The PSP specifically switched between its cis and trans photostationary states on exposure to 364 nm and 440 nm wavelength lights respectively, which not only provided the ability to control its pore diameter but also the surface chemistry. The switchable molecular transport properties of the PSP-NAAMs have been shown as a function of the light exposure. Most importantly, the molecular transport across PSP-NAAMs could be repeatedly switched between on and off state, which is highly significant for on-demand triggered drug release systems.

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Tushar Kumeria, Jingxian Yu, Mohammed Alsawat, Mahaveer D. Kurkuri, Abel Santos, Andrew D. Abell, and Dusan Losic "Modulating molecular transport across peptide-modified nanoporous alumina membranes with light", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100131W (9 December 2016); https://doi.org/10.1117/12.2241495

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