Shapeshifting photoswitchable azobenzene compounds and their biological applications

Victoria Peddie; Sabrina Heng; Sanam Mustafa; Jacob Thomas; Mark R. Hutchinson; Andrew D. Abell

doi:10.1117/12.2242356

24 November 2016 Shapeshifting photoswitchable azobenzene compounds and their biological applications

Victoria Peddie, Sabrina Heng, Sanam Mustafa, Jacob Thomas, Mark R. Hutchinson, Andrew D. Abell

Proceedings Volume 10013, SPIE BioPhotonics Australasia; 100132W (2016) https://doi.org/10.1117/12.2242356
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

The photoisomerisation of azobenzenes between trans and cis results in well-defined changes in geometry and a considerable change of polarity. Thus, incorporating an azobenezene into a bioactive compound provides an opportunity to control biological activity, with ideally one configuration being active and the other inactive. This can allow the role of a specific biomolecule to be probed in its native environment by controlling activity both spatially and temporally using light. Incorporating such a photoswitchable moiety into the structure of a known GRK2 inhibitor can generate photoswitchable inhibitors, which can be used to reversibly regulate the activity of GRK2, and hence GPRCs.

Citation Download Citation

Victoria Peddie, Sabrina Heng, Sanam Mustafa, Jacob Thomas, Mark R. Hutchinson, and Andrew D. Abell "Shapeshifting photoswitchable azobenzene compounds and their biological applications", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100132W (24 November 2016); https://doi.org/10.1117/12.2242356

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available