24 November 2016 Shapeshifting photoswitchable azobenzene compounds and their biological applications
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The photoisomerisation of azobenzenes between trans and cis results in well-defined changes in geometry and a considerable change of polarity. Thus, incorporating an azobenezene into a bioactive compound provides an opportunity to control biological activity, with ideally one configuration being active and the other inactive. This can allow the role of a specific biomolecule to be probed in its native environment by controlling activity both spatially and temporally using light. Incorporating such a photoswitchable moiety into the structure of a known GRK2 inhibitor can generate photoswitchable inhibitors, which can be used to reversibly regulate the activity of GRK2, and hence GPRCs.
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Victoria Peddie, Victoria Peddie, Sabrina Heng, Sabrina Heng, Sanam Mustafa, Sanam Mustafa, Jacob Thomas, Jacob Thomas, Mark R. Hutchinson, Mark R. Hutchinson, Andrew D. Abell, Andrew D. Abell, } "Shapeshifting photoswitchable azobenzene compounds and their biological applications", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100132W (24 November 2016); doi: 10.1117/12.2242356; https://doi.org/10.1117/12.2242356

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