9 December 2016 Polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors
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The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics is strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation property. Due to the co-existence of Au NSs and the pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow their uses as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. With the easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be developed as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancer.
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Du Li, Du Li, Xiangyang Shi, Xiangyang Shi, Dayong Jin, Dayong Jin, } "Polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100133L (9 December 2016); doi: 10.1117/12.2245310; https://doi.org/10.1117/12.2245310

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