The optical and acoustic fields of stimulated Brillouin scattering (SBS) effect in the As2S3 chalcogenide suspended-core microstructured optical fibers (MOFs) are investigated by the finite-element method (FEM). The optical and acoustic fundamental modes at 1550 nm are analyzed with the core diameters of the MOFs varying from 1.0 to 6.0 μm. For each case, the holes of the MOFs are filled with different materials such as trichlormethane (CHCL3), alcohol and water. When the core diameter is 6.0 μm, the maximum peak intensity of the optical fundamental mode is in the case with air holes, while the minimum value is in the case filled with CHCL3. The ratio of difference is ~0.66%. The minimum peak intensity of the acoustic fundamental mode is in the case with air holes, while the maximum value is in the case filled with water. The ratio of difference is ~0.13%. The same rule occurs in the fiber cores of 4.5, 3.0 and 2.0 μm, where the decreases of ~0.97%, 1.48%, 1.94% for optical field and the increases of ~0.24%, 0.34%, 0.74% for acoustic field are obtained, respectively. When the core diameter is 1.0 μm, ratios of difference for optical and acoustic fields are much higher than those in the cases of 2.0-6.0 μm, which are ~3.55% and 29.13%, respectively. The overlap factors between optical and acoustic fields are calculated, which are changed with the core diameter and the filled material in holes. Our results will be helpful to strengthen or suppress the SBS effect in practical applications.