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31 October 2016 Effect of surface topographic features on the optical properties of skin: a phantom study
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Tissue-simulating phantoms are used to validate and calibrate optical imaging systems and to understand light transport in biological tissue. Light propagation in a strongly turbid medium such as skin tissue experiences multiple scattering and diffuse reflection from the surface. Surface roughness introduces phase shifts and optical path length differences for light which is scattered within the skin tissue and reflected from the surface. In this paper, we study the effect of mismatched surface roughness on optical measurement and subsequent determination of optical properties of skin tissue. A series of phantoms with controlled surface features and optical properties corresponding to normal human skin are fabricated. The fabrication of polydimethylsiloxane (PDMS) phantoms with known surface roughness follows a standard soft lithography process. Surface roughness of skin-simulating phantoms are measured with Bruker stylus profiler. The diffuse reflectance of the phantom is validated by a UV/VIS spectrophotometer. The results show that surface texture and roughness have considerable influence on the optical characteristics of skin. This study suggests that surface roughness should be considered as an important contributing factor for the determination of tissue optical properties.
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Guangli Liu, Jianfeng Chen, Zuhua Zhao, Gang Zhao, Erbao Dong, Jiaru Chu, and Ronald X. Xu "Effect of surface topographic features on the optical properties of skin: a phantom study", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100240O (31 October 2016);

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