31 October 2016 Hemoglobin concentration determination based on near infrared spatially resolved transmission spectra
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Abstract
Spatially resolved diffuse reflectance spectroscopy method has been proved to be more effective than single point spectroscopy method in the experiment to predict the concentration of the Intralipid diluted solutions. However, Intralipid diluted solution is simple, cannot be the representative of turbid liquids. Blood is a natural and meaningful turbid liquid, more complicate. Hemoglobin is the major constituent of the whole blood. And hemoglobin concentration is commonly used in clinical medicine to diagnose many diseases. In this paper, near infrared spatially resolved transmission spectra (NIRSRTS) and Partial Least Square Regression (PLSR) were used to predict the hemoglobin concentration of human blood. The results showed the prediction ability for hemoglobin concentration of the proposed method is better than single point transmission spectroscopy method. This paper demonstrated the feasibility of the spatially resolved diffuse reflectance spectroscopy method for practical liquid composition analysis. This research provided a new thinking of practical turbid liquid composition analysis.
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Linna Zhang, Linna Zhang, Gang Li, Gang Li, Ling Lin, Ling Lin, } "Hemoglobin concentration determination based on near infrared spatially resolved transmission spectra", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100241O (31 October 2016); doi: 10.1117/12.2243796; https://doi.org/10.1117/12.2243796
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