31 October 2016 Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging
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Abstract
Multi-spectral photoacoustic (MSPA) imaging can extract quantitative information of interesting component from morphological photoacoustic image of targets. A probe with an optimal optical absorption can be detected by MSPA imaging with higher sensitivity and specificity. Here we developed a Nano polymers dots (P-dots) for MSPA imaging that has a high photoacoustic conversion efficiency in a broad optical absorbing band (500 nm - 700 nm). In vivo MSPA imaging experiment was successfully performed in mouse model. The relative concentration map of P-dots was exactly obtained from the background of tissues, which demonstrated the potential use of P-dots in the bio-imaging field based on MSPA imaging.
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Jian Zhang, Zhen Yuan, "Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242A (31 October 2016); doi: 10.1117/12.2245654; https://doi.org/10.1117/12.2245654
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