A method to improve the measurement stability of scattering coefficients in lip  with optical coherence tomography

Xiyang Zhang; Ying Zhang; Zhifang Li; Hui Li

doi:10.1117/12.2245714

Abstract

Optical coherence tomography (OCT) is a non-invasive imaging technique that provides real-time two- and three-dimensional images of scattering tissues with micrometer resolution. Scattering coefficient is estimated based on the slope of OCT dependent of depth. However, stability of the OCT signal slope is dependent on tissue heterogeneity. Our work is to provide a method of combining post-processing Fourier filtration with automatic identification of fitting range to reduce the effect of tissue heterogeneity on scattering coefficient, and used for noninvasive monitoring of glucose concentration in lip. Axial and lateral resolutions of OCT are 20 μm and 15 μm respectively. OCT images were obtained from lip before breakfast and after breakfast respectively. Results demonstrate that the method improve the stability and the precision of measurement of scattering coefficient of lip. There are obviously different in scattering coefficient of tissue between preprandial glucose and 2-hours postprandial glucose. These pilot studies show that OCT scattering coefficient extraction of lip may be considered as a significant diagnostic marker. OCT has potential to monitor glucose-induced changes in lip in vivo.

Citation Download Citation

Xiyang Zhang, Xiyang Zhang, Ying Zhang, Ying Zhang, Zhifang Li, Zhifang Li, Hui Li, Hui Li, } "A method to improve the measurement stability of scattering coefficients in lip with optical coherence tomography", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242G (31 October 2016); doi: 10.1117/12.2245714; https://doi.org/10.1117/12.2245714

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years