Childhood lymphoblastic leukemia adverse drug reactions: study of risk factors and therapy prognosis by optical methods

A. Zyubin; A. Lavrova; S. Babak; V. Malashchenko; A. Borisova; N. Opryshko

doi:10.1117/12.2246024

31 October 2016 Childhood lymphoblastic leukemia adverse drug reactions: study of risk factors and therapy prognosis by optical methods

A. Zyubin, A. Lavrova, S. Babak, V. Malashchenko, A. Borisova, N. Opryshko

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 1002432 (2016) https://doi.org/10.1117/12.2246024
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

The treatment of acute lymphoblastic leukemia (ALL) can result in the side-effects such as kidney affection, hepatic failure and tissue hypoxia. We study dynamics of special biochemical marker of these pathologies - adenosine triphosphate, that is well-known substance of energy metabolism. We use methods of confocal microscopy for determining the cellular and mitochondrial concentration of adenosine triphosphate (ATP). Quantitative values of adenosine triphosphate were calculated for each patient and correlation with degree of side-effects had been done. The application of confocal microscopy for studying of side-effects and therapy of lymphoblastic leukemia is discussed.

Citation Download Citation

A. Zyubin, A. Lavrova, S. Babak, V. Malashchenko, A. Borisova, and N. Opryshko "Childhood lymphoblastic leukemia adverse drug reactions: study of risk factors and therapy prognosis by optical methods", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 1002432 (31 October 2016); https://doi.org/10.1117/12.2246024

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