4 November 2016 Gold nano sphere based fiber optic LSPR probe for biosensing measurement
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Abstract
We present a localized surface plasmon resonance fiber optic biosensor based on an intensity interrogation mechanism. A layer of gold nano sphere is deposited on a fiber optic sensor probe which works as the sensing element and is immobilized on the sidewall of an unclad optical fiber via two different immobilization methods (amino silane method and layer by layer self-assembly method). Different self-assembly layers were also respectively investigated by using layer by layer self-assembly method to explore the optimum layer number. Experimental results reveal that PDDA/PSS/PAH layer self-assembly method provides the best LSPR response. We obtain a refractive index sensitivity as 6.57RIU-1 in a RI range of 1.3266~1.3730. We also conduct real-time and label free monitoring of Ribonuclease B/Con A biomolecular interaction by using this sensor prototype and demonstrate it can perform qualitative and quantitative detection in real-time biomolecular sensing.
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Lixia Li, Lixia Li, Zigeng Liu, Zigeng Liu, Shimeng Chen, Shimeng Chen, Jianye Guang, Jianye Guang, Wei Peng, Wei Peng, } "Gold nano sphere based fiber optic LSPR probe for biosensing measurement", Proc. SPIE 10027, Nanophotonics and Micro/Nano Optics III, 100270M (4 November 2016); doi: 10.1117/12.2245960; https://doi.org/10.1117/12.2245960
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