Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

Santosh Balakrishnan; Ruofei Bu; Hillel Price; Carlton Zdanski; Amy L. Oldenburg

doi:10.1117/12.2250348

14 February 2017 Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

Santosh Balakrishnan; Ruofei Bu; Hillel Price; Carlton Zdanski; Amy L. Oldenburg

Author Affiliations +

Proceedings Volume 10039, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology; 1003907 (2017) https://doi.org/10.1117/12.2250348
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the aOCT catheter may be visualized with CT to aid in co-registration. Utilizing this setup we investigate multiple respiratory pressure parameters with aOCT, and respiratory-gated CT, on both ex vivo porcine trachea and live, anesthetized pigs. This acquisition protocol has enabled real-time measurement of airway deformation with simultaneous measurement of pressure under physiologically relevant static and dynamic conditions- inspiratory peak or peak positive airway pressures of 10-40 cm H₂O, and 20-30 breaths per minute for dynamic studies. We subsequently compare the airway cross sectional areas (CSA) obtained from aOCT and CT, including the change in CSA at different stages of the breathing cycle for dynamic studies, and the CSA at different peak positive airway pressures for static studies. This approach has allowed us to improve our acquisition methodology and to validate aOCT measurements of the dynamic airway for the first time. We believe that this protocol will prove invaluable for aOCT system development and greatly facilitate translation of OCT systems for airway imaging into the clinical setting.

Citation Download Citation

Santosh Balakrishnan, Santosh Balakrishnan, Ruofei Bu, Ruofei Bu, Hillel Price, Hillel Price, Carlton Zdanski, Carlton Zdanski, Amy L. Oldenburg, Amy L. Oldenburg, } "Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging", Proc. SPIE 10039, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology, 1003907 (14 February 2017); doi: 10.1117/12.2250348; https://doi.org/10.1117/12.2250348

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years