15 February 2017 Chip-on-the-tip ultra-compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medical and biomedical fields
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Proceedings Volume 10040, Endoscopic Microscopy XII; 1004007 (2017) https://doi.org/10.1117/12.2251827
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
We demonstrate a flexible stand-alone, minimally invasive video-endomicroscope with an outer diameter of 1.6 mm and a length of the rigid tip of 6.7 mm that enables surgeons and biologists to image hardly accessible regions in-vivo in epifluorescence mode. The 60 mg light device improves state-of-the-art objectives by a double deflection approach using a side-fire fiber in combination with spherical microlenses, GRIN-lenses with a specific adapted gradient index profile and an extremely miniaturized chip-on-the-tip camera to achieve an excellent imaging quality. A high NA of 0.7 enables the observation of subcellular features within the entire field of view with a diameter of 183 μm, assure a bright and high-contrast image and promise a good overview during the intervention. Ex-vivo measurements of biological samples confirmed the functionality of the probe.
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Gregor Matz, Gregor Matz, Bernhard Messerschmidt, Bernhard Messerschmidt, Werner Göbel, Werner Göbel, Severin Filser, Severin Filser, Christian Betz, Christian Betz, Marcel Kunze, Marcel Kunze, Sven Flaemig, Sven Flaemig, André Ehrhardt, André Ehrhardt, Klaus-Martin Irion, Klaus-Martin Irion, Jochen Herms, Jochen Herms, Herbert Gross, Herbert Gross, } "Chip-on-the-tip ultra-compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medical and biomedical fields", Proc. SPIE 10040, Endoscopic Microscopy XII, 1004007 (15 February 2017); doi: 10.1117/12.2251827; https://doi.org/10.1117/12.2251827
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