2 March 2017 Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
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Abstract
Preterm birth (PTB) presents a serious medical heath concern in both economically developed and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent biological tissue such as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG) microscopy were used to assess cervical collagen content and structure in non-pregnant cervices. In vivo studies using a Mueller Matrix colposcope are underway. Further studies of cervical collagen orientation throughout pregnancy are needed to understand if Mueller matrix polarimetry can effectively identify at-risk conditions for PTB.
Conference Presentation
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Karla A. Montejo, Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, Nola Holness, Mariacarla Gonzalez, Jefferson Gomes, Amir Gandjbakhche, Viktor V. Chernomordik, Jessica C. Ramella-Roman, "Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy", Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 1004303 (2 March 2017); doi: 10.1117/12.2250987; https://doi.org/10.1117/12.2250987
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