2 March 2017 Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
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Abstract
Preterm birth (PTB) presents a serious medical heath concern in both economically developed and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent biological tissue such as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG) microscopy were used to assess cervical collagen content and structure in non-pregnant cervices. In vivo studies using a Mueller Matrix colposcope are underway. Further studies of cervical collagen orientation throughout pregnancy are needed to understand if Mueller matrix polarimetry can effectively identify at-risk conditions for PTB.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Karla A. Montejo, Karla A. Montejo, Joseph Chue-Sang, Joseph Chue-Sang, Yuqiang Bai, Yuqiang Bai, Susan Stoff, Susan Stoff, Nola Holness, Nola Holness, Mariacarla Gonzalez, Mariacarla Gonzalez, Jefferson Gomes, Jefferson Gomes, Amir Gandjbakhche, Amir Gandjbakhche, Viktor V. Chernomordik, Viktor V. Chernomordik, Jessica C. Ramella-Roman, Jessica C. Ramella-Roman, } "Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy", Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 1004303 (2 March 2017); doi: 10.1117/12.2250987; https://doi.org/10.1117/12.2250987
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