UV-A/riboflavin collagen cross-linking (UV-CXL) is a clinical treatment for keratoconus that stiffens mechanically
degraded corneal tissue. On the other hand, the intraocular pressure (IOP) can also affect the measured cornea elasticity.
However, the combined effects of CXL at different IOPs on the corneal biomechanical properties are not well
understood. In this work, the feasibility of assessing the viscoelasticity of the porcine cornea before and after CXL at
various IOPs was investigated by using a noncontact method of optical coherence elastography (OCE) and a modified
Lamb wave model. The modified wave model was first verified by comparison with finite element modeling, and then
utilized to quantify the viscoelasticity of porcine corneas in the whole eye-globe configuration before and after CXL
treatment at various IOPs. The results show that the elasticity of the cornea increased after CXL and that corneal stiffness
was linear as a function of IOP. At IOPs of 15, 20, 25, and 30 mmHg, the relative increase in Young’s modulus after
CXL was ~109%, ~86%, ~64%, and ~79%, respectively, while the shear viscosity decreased by ~86%, ~84%, ~83%,
and ~81%. The modified Lamb wave model and OCE show promise for quantifying corneal viscoelasticity, which could
provide a basis for customized CXL therapies and accurate disease detection.